AIM:To explore the effects of qingguangan on retinal structure and apoptosis in rabbit eyes with acute ocluar hypertension.METHODS:Forty-nine rabbits were divided into 7 groups randomly,7 rabbits in each group. Group A1 and A2 belonged qing-guangan group.Group B1 and B2 belonged to eyesight-improving bolus of noble dendrobium group.C1 and C2 were model group.Group D was blank control group.After administrated qingguangan intragastrically for one week rabbits were filled normal saline into anterior chamber to make acute ocular hypertension model. Then after rabbits were administrated qingguangan intragastrically for one week and two weeks all were killed. Retinal ulstructure changes were observed in light microscope and transmission electron microscope,while apoptosis was observed in light microscope.RESULTS:Retinal structures were not different in one week and two weeks. Layers of the retina model group and eyesight-improving bolus of noble dendrobium group were disorder and cell numbers decreased. The number of apoptotic bodies of two groups were more than those of qingguangan group. Ganglion nuclear membrane of two groups were less clear. Most of mitochondria were swelling and there was condensation phenomenon,rough endoplasmic reticulum dilation.But changes above mentioned in qingguangan group were not obvious.CONCLUSION:Qingguangan has the effects of protecting retinal structure and reducing apoptosis.