目的:研究鱼腥草滴眼液联合人工泪液治疗干眼的效果。方法:干眼患者130例244眼随机分为对照组和试验组,以人工泪液和生理盐水滴眼为对照,鱼腥草滴眼液联合和人工泪液治疗为试验组,患者自觉症状、泪膜破裂时间(breaking up time,BUT)、泪液分泌时间(schirmerⅠtest,SⅠt)的变化,并采用结膜印迹细胞学检查(conjunctival impression cytology,CIC)观察眼表结构的改善情况。结果:两组治疗后患者自觉症状均有不同程度改善,对照组BUT较治疗前虽有延长(P<0.05),但SⅠt和CIC评分无明显好转;试验组治疗后BUT,SⅠt及CIC评分较治疗前均有明显改善,且改善程度优于对照组(P<0.01)。结论:鱼腥草滴眼液联合人工泪液治疗干眼依从性好,疗效高。

AIM:To investigate the therapeutic effect and clinical value of houttuynia cordata eyedrops combining with artificial tear in the treatment of dry eye.METHODS:One hundred and thirty patients (244 eyes) with dry eye were randomized into control and experimental group. Artifical tear and normal saline were used in control group,whereas houttuynia cordata eyedrops and artificial tear were prescribed in the experimental group. The subjective symptom and the results of tear break-up time (BUT) and Schirmer Ⅰ test (SⅠt) were analyzed. The improvement of ocular surface were examined by conjunctival impression cytology(CIC).RESULTS:The subjective symptom of the patients were improved at different degree in the two groups. Although the BUT prolonged (P<0.05),there were no significant improvement in the result of SⅠt and the Nelson grade of CIC post treatment in control group(P>0.05). However,the results of BUT,SⅠt and grade of CIC of the experimental group were all imroved significantly than that of pretherapy,and the degree of improvement were better than that of control group (P<0.01).CONCLUSION:Houttuynia cordata eyedrops combining with artificial tear is a simple and effective method for the treatment of dry eye and is beneficial to enhance the therapeutic compliance and effect.

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