AIM:To evaluate the feasibility of mitomycin C (MMC) in preventing haze in LASEK surgery of high myopia.METHODS:Twenty-four high myopia patients(48 eyes) were randomly divided into two groups,one group included 11 patients(22 eyes) which operated LASEK surgery as usual and the other group(26 eyes) received 0.2g/L MMC sponge in the operation,and the time lasted for 12 seconds. After operation and the cornea was covered with gas-permeable soft contact lens. All of the patients were followed up,including vision and haze etc. for half a year. RESULTS:There was no difference of the haze between the two groups 6 weeks after the operation. 3 months,6 months after operation the haze in MMC group was lighter than that of the control group (P<0.05). CONCLUSION:MMC seems to be effective to prevent the haze in the surgery of LASEK of high myopia.