目的:观察贝母素甲(PM)对体外培养甲状腺相关眼病患者眼眶成纤维细胞(orbital fibroblast,OF)增殖的影响。方法:采用体外培养的正常人和甲状腺相关眼病患者的OF,将PM和阳性对照药物地塞米松(Dex)分成不同浓度组,以MTT法检测其对细胞增殖的影响。结果:对体外培养甲状腺相关眼病患者OF的增殖,PM具有与Dex相似的抑制作用,二者均有明显的剂量依赖性。但PM对甲状腺相关眼病患者OF增殖的抑制作用明显优于正常人(P<0.05),而Dex则无此选择性。结论:浙贝抑制了甲状腺相关眼病患者OF的增殖。

AIM:To observe the influence of the Fritillaria thun-bergii’s extract on the proliferation of the cultured orbital fibroblasts (OF) of the thyroid-associated ophthalmo-pathy (TAO)-patients.·METHODS:The cultured OF of the normal and the TAO-patients was introduced.The Fritillaria thunbergii’s extract and the Dexamethasone(Dex) as the positive contrast medicine were devided into different groups to detect the influence of the Fritillaria thunbergii’s extract on the proliferation of the cultured OF of the normal and the TAO-patients by the MTT method.·RESULTS:The Fritillaria thunbergii’s extract showed a similar result to Dex in inhibiting the prolife-ration of cultured OF of the TAO-patients,and both of them showed the dose-dependence.But the inhibition of the Fritillaria thunbergii’s extract to the proliferation of the TAO-patients’ OF was better than the normal obviously (P<0.05),and the Dex had no this selectivity.·CONCLUSION:The Fritillaria thunbergii inhibit the proliferation of TAO-patients’ OF.

R771.3