AIM:To investigate the effects of comprehensive perioperative treatment on patients with both glaucoma and cataract.·METHODS:Small-incision manual nuclear fragmentation cataract extraction with implantation of posterior chamber intraocular lens (IOL) combined with trabeculectomy was performed on 79 eyes of 65 cases under topical anesthesia.The anesthesia effect was evaluated.The data of the postoperative vision,the intraocular pressure(IOP) and the count of the corneal endothelial cells were analyzed.·RESULTS:There were 97.5% patients satisfied with the anesthesia effect.All patients got improved vision and had steady IOP.The average loss of the count of corneal endothelial cells was 6.9%.·CONCLUSION:It was effective and safe to perform small-incision manual nuclear fragmentation cataract extraction with implantation of posterior chamber IOL combined with trabeculectomy on patients with both glaucoma and cataract under topical anesthesia.