AIM:To observe the clinical effect of wavefront aberration and iris location guided epipolis laser in situ keratomileusis( EPI-LASIK )for high myopia.·METHODS:Fifty-four patients(108 eyes)with corneal high myopia were randomly divided into wavefront aberration and iris location guided EPI-LASIK group of twenty-nine patients (58 eyes)and conventional EPI-LASIK group of twenty-five patients (50 eyes).The uncorrected visual acuity(UCVA),refractions,vision quality and high-order aberration value were analyzed during the postoperative follow-up.·RESULTS:At 6th month postoperatively,there was no significant diference of the UCVA (P>0.05)between two groups;The postoperative UCVA of all eyes was satisfied,gained over 2 line of best-corrected visual acuity(BCVA) in wavefront guided group and gained over 2 line of BCVA in conventional group,there was significant diference between the two group(P<0.01);The postoperative refractions,vision quality was statistically different between the conventional group and wavefront guided group(P<0.05);there was significant difference in the postoperative high-order aberration between the two groups(P<0.01).·CONCLUSION:The wavefront aberration and iris location guided EPI-LASIK in some field is better than conventional EPI-LASIK for the treatment of high myopia.·