AIM:To analyze the natural course of acute angle-closure glaucoma and to explore the effect factors of vision and personalized treatment.·METHODS:Clinical data of 205 cases of acute angle-closure glaucoma patients,including current medical history,preoperative examination,timing of surgical treatment,surgical options and post-operative complications of treatment,discharge and impact of visual factors,follow-up data were retrospectively analyzed.·RESULTS:The information collected from 205 cases,with seven cases of drug treatment,198 cases of surgical treatment (96.6%).Of the 198 cases of surgical eyes,vision decreased at discharge in 108 cases (54.6%),remained the same in 42 cases (21.2%),improved in 48 cases (24.2%);7 cases of the eyes without surgery remained unchanged in 6 cases,1 case improved.There were 101 cases of complicated cataract,89 cases of iris atrophy and fixed mydriasis.·CONCLUSION:The acute angle-closure glaucoma is a group of relatively independent anterior segment syndrome,in addition to optic nerve damage,interstitial damage of the high intraocular pressure,such as cornea,iris,and lens,is also an important reason for decreased vision.Acute angle-closure glaucoma treatment should be different for different patients,with the phased implementation of personalized treatment.