·AIM:To study the mechanism on signal transduction of proliferation induced by urotensin-Ⅱ(U-Ⅱ)in lens epithelial cell(LEC).·METHODS:U-Ⅱ were incubated with cultured LEC.Meanwhile four blockers of signal transduction,H7,PD98059,W7 and nicardipine,were incubated with LEC separately.Then the proliferations of LEC were detected via 3H-TdR incorporation.·RESULTS:The radioactivity of 3H-TdR in U-Ⅱ group was higher than that in control group(P<0.01).The radioactivities of 3H-TdR in groups of four blockers decreased in varying degrees compared with U-Ⅱ group(P<0.01,P<0.01).The blocking effects of PD98059 and H7 were higher than that of nicardipine and W7(F= 13.251,P<0.01).·CONCLUSION:U-Ⅱ induced LEC proliferation by means of signal trasduction which can be blocked by four signal transduction blockers.The result provides a new thinking for prevention and treatment of after cataract.·