·AIM:To observe the features and the clinical significance of fundus fluorescein angiography(FFA)and indocyanine green angiography(ICGA)in multifocal posterior pigment epitheliopathy(MPPE).·METHODS:The clinical data of 35 cases(51 eyes)with MPPE during Jan.2007 to Apr.2009 were analyzed retrospectively.All the patients received the conventional examination,including the vision,slit-lamp,the direct/indirect ophthalmoscope examination,and the fundus color photography,FFA and ICGA with heidelberg retinal confocal laser instrument(HRA-2)were also carried out.·RESULTS:The multifocal retinal pigment epithelial(RPE)leakage and choroidal circulatory disturbances(including choroidal vascular filling delay as well as the expansion/leakage of choroidal blood vessels)were the main features of the MPPE in active phase examined by FFA and ICGA.Some patients occured the exudative retinal detachment for a large number of RPE leakage and a long time leakage,in which some changes similar to chronic uveitis appeared in a small part of patients including the leakages of retinal vessels,retinal non-perfusion areas and neovascularization,the disc with strong fluorescence in the FFA later phase.The chief changes were the RPE and choriocapillaris atrophy in FFA and ICGA with the MPPE in quiescent phase,but the choroidal circulation anomalies disappeared including the choroidal filling delay and dilated.·CONCLUSION:The MPPE patients have similar changes with central serous chorioretinopathy(CSC)in FFA and ICGA,but the degree is more serious,in which some patients can be accompanied with some similar changes with chronic uveitis.The black infrared fluorescent focus in ICGA during the late phase will help us to judge the prognosis of the MPPE.·