目的:探讨准分子激光原位角膜磨镶术(LASIK)术中负压吸引时间对角膜瓣厚度和直径的影响。方法:根据负压吸引时间的不同将60只猪眼随机分为3组:组1(10s)、组2(20s)和组3(30s),使用法国产MoriaM2型角膜板层刀分别吸引角膜10s,20s和30s后切削角膜瓣,利用角膜超声测厚仪测量角膜瓣厚度,应用镀铬游标卡尺测量角膜瓣直径。结果:组1、2和3角膜瓣厚度分别为146.05±13.46,157.35±18.95和169.25±21.02μm,各组间比较有显著性差异(P=0.001)。各组的平均角膜瓣直径分别为8.63±0·19mm(组1,10s),8.89±0.24mm(组2,20s)和9.06±0·18mm(组3,30s)。各组间比较有显著性差异(P<0·01)。结论:LASIK术中随着负压吸引时间的延长,角膜瓣厚度和直径均增加。

AIM: To determine the effect of suction duration on thickness and diameter of corneal flap created by microkeratome in porcine eyes in laser in situ kerato-mileusis (LASIK). METHODS:Sixty porcine eyes were randomly assigned to three groups according to different suction durations:group 1 (10 seconds),group 2 (20 seconds),and group 3 (30 seconds).A Moria M2 microkeratome (Moria, France) with a 160μm head was used to create a corneal flap. Corneal flap thickness was measured by automated ultrasonic pachymetry, and the flap diameter was measured by a vernier caliper. RESULTS: The flap thickness of group 1, group 2 and group 3 was 146.05±13.46μm, 157.35±18.95μm and 169.25±21.02μm, respectively. There was a statistically significant difference among three groups (P=0.001). The mean flap diameter in groups 1, 2 and 3 was 8.63±0.19mm, 8.89±0.24mm and 9.06±0.18mm, respectively. A statisti-cally significant difference was found among groups (P<0.01). CONCLUSION: In LASIK in porcine eyes, an increase in suction duration resulted in a thicker and greater flap.

R779.63

中国辽宁省自然科学基金资助项目（No.20042081）