目的:探讨中药杏丁叶提取物银杏达莫注射液拮抗糖尿病患者内皮素的作用。方法:观察各期Ⅱ型糖尿病患者58例,用银杏达莫注射液25mL加入生理盐水250mL中,1次/d,15d为一疗程,测定治疗前后血浆内皮素含量。结果:治疗前平均血浆内皮素78.32pg/mL,(参考值:37.91~68.37pg/mL),最高105.68pg/mL,治疗后平均血浆内皮素水平59.57pg/mL,平均下降18.75pg/mL,差异具有统计学意义(P<0.05)。结论:银杏达莫注射液能有效降低糖尿病患者血浆内皮素水平,对糖尿病性视网膜病变患者有治疗作用。

AIM: To discuss the antagonistic role of traditional Chinese medicine leaf of xingding extract-the ginkgo biloba injection on endothelin(ET) in diabetic retinopathy(DR) patients. METHODS: A total of 58 DR patients were enrolled in the study, DR patients were administered with 25mL ginkgo-dipyridamolum injection which was dissolved in 250mL normal saline, once a day for 15 days. The ET in their peripheral blood was measured before and after treatment. RESULTS: The mean value of plasma ET before treatment was 78.32pg/mL (reference value: 37.91-68.37pg/mL) and the highest value was 105.68pg/mL. The mean plasma ET level after treatment was 59.57pg/mL, which averagely decreased 18.75pg/mL as compared with that before the treatment. There was a significant difference between them(P<0.05). CONCLUSION: The ginkgo biloba injection can effectively decrease the plasma ET level of DR patients, which has a therapeutic effect on DR.