·AIM:To compare the clinical effects of Acrysof ReSTOR multifocal intraocular lens(IOL)and the monofocal Acrysof Natural IOL implantation after phacoemulsification.·METHODS:Random clinical trial of 58 patients 66 eyes with age-related cataract were divided into two groups:ReSTOR group included 30 patients 36 eyes implanted with ReSTOR SA60D3 multifocal IOL(MIOL),and Natural group included 28 patients 30 eyes implanted with Natural SN60AT monofocal IOL.Measurements were taken after operation,including uncorrected distant visual acuity(UCDVA),uncorrected near visual acuity(UCNVA),best corrected distant visual acuity(BCDVA),best-corrected near visual acuity(BCNVA),distant corrected near visual acuity(DCNVA),intermediate vision(40,60,80cm)and visual symptoms.·RESULTS:There was no significant difference in UCDVA,BCDVA,BCNVA between 2 groups.UCNVA,DCNVA and intermediate vision(40,60,80cm)were significantly higher in the ReSTOR group(P<0.05).In ReSTOR group the UCDVA、UCNVA at 4 weeks were significantly better than that of 1 week.At the 12 weeks postoperatively,UCNVA was significantly better than intermediate vision(40cm)in ReSTOR group and no statistical difference was noted between the intermediate vision(40 vs 60cm,60 vs 80cm).Adverse symptoms such as glare and haloes were significantly more obvious in ReSTOR group than in Natural group(P<0.05).The rate of dependence on glasses in the ReSTOR group was significantly lower than that of Natural group(P<0.05).·CONCLUSION:Acrysof ReSTOR multifocal IOL provide excellent full range of vision,effectively decrease the dependence of glasses,improve the visual quality after surgery.·