·AIM:To investigate the corneal surface regularity and symmetry after optimized refractive keratectomy-customized ablation(ORK)surgery for treatment of high myopia.·METHODS:Fifty patients 100 eyes with high myopia underwent optimized refractive keratectomy-customized ablation therapy,and for the same period 50 patients 100 eyes with high myopia were treated with conventional LASIK,the effect of two groups was observed,and the corneal topography changes,including corneal curvature,K1,K2,surface asymmetry index(SAI),surface regularity index(SRI)of the two groups after 6 months were observed with corneal topography.·RESULTS:Compared with that of preoperative,postoperative corneal curvature,K1,K2,decreased,SAI,SRI reduced(each P <0.05).The improvement of was SAI and SRI in ORK group after 6 months superior to that in the LASIK group(each P<0.05).·CONCLUSION:The cornea of the patients who underwent optimized refractive keratectomy-customized ablation therapy is more of regularity and symmetry than that of conventional LASIK patients after 6 months.·