·AIM:To observe the clinical effect and feasibility of biological amniotic membrane transplantation combined with remedial contact lens in corneal ulcer.·METHODS:Thirty-five eyes of 33 patients with corneal ulcer were cut the ulcer lesions firstly,then the biological amniotic membrane was applied to the ulcer area.The amniotic membrane was interruptedly sutured to the healthy cornea.On the second day of post-operation the patients wore remedial contact lens,and therapeutic eyedrops were used.·RESULTS:The anterior chamber of all the patients recovered in 1-2 days,and the local irritation improved obviously.The mean healing time was 30-45 days.5 cases occurred corneal neovascularization and cicatrization.The anterior chamber in 2 patients disappeared repeatedly and penetrated corneal transplantation was performed finally.The visual acuity of all patients improved after treatment.·CONCLUSION:Biological amniotic membrane trans-plantation combined with remedial contact lens are effective for corneal ulcer,and creat favourable local condition for later corneal transplantation.·