AIM:To evaluate the feasibility of the clinical therapy in amblyopia with primary microtpia METHODS: The therapia was observed for 1-3 years in 37 patients,and the retrospective study was performed to analyze the therapeutic effect in different amblyopia degree,or in different age group,or in different fixationism, their impact on therapeutic effect was analyzed by statistical analysis. RESULTS: The total effective rate was 76% in their therapia,the cure rate was 22%,31% recovered the stereopsis, the therapeutic effect was uniformity in different amblyopia degree,or in different age group,the therapeutic effect was different in different fixationism (P<0.05).CONCLUSION: Treatment of amblyopia with primary microtpia is feasible in different amblyopia degree,or in different age group .Further theory, clinical research and effective therapeutic regimen are necessary to improve the cure rate.