AIM:To establish the inflammatory retinal edema animal model and research the influence of the baicalin on the inflammatory retinal edema.METHODS:Opitical coherence tomograph (OCT) was used to survey the effect of baicalin on the retina thickness in inflammatory retinal edema.15 inflammation-mediated rabbits were randomly assigned to five groups,each group included 3 rabbits(6 retinas),which received different treatments,respectively:baicalin(160mg/L,20mL/kg) by iv.administration bid;baicalin (40mg/L,20mL/kg) by iv.administration bid;baicalin (10mg/L,20mL/kg) by iv.administration bid;triamcinolone acetonide(TA) retrobulbar injection of 20mg respectively;the control group was injected physiologic saline in the same volume.The effect was measured by the thickness of retinas of OCT on day 1,2,4,6,10,14 and 21 respectively.RESULTS:Compared with the inflammatory control group,the thickness of baicalin group reduced apparently,the difference was remarkable(P<0.01),and the difference between baicalin group and TA group after 2 days were not statistically significant(t<2.447,P>0.05).CONCLUSION:The baicalin could suppress the inflammatory retina cell edema effectively,it even has the same drug efficacy with the TA,and no obvious poisonous side effect.