AIM:To evaluate the clinical effects of iris location combined wave-front aberration guided laser in situ kerat-omileusis (LASIK) in the treatment of higher astigmatism.METHODS:Iris location combined wave-front aberration guided LASIK was performed in 39 patients 73 eyes as the experimental group,and traditional LASIK was performed in 37 patients 70 eyes as the control group.The therapeutic effects were compared between two groups.RESULTS:Three months postoperatively,the postoperative naked vision of 71 eyes (97%) in experimental group and 57 eyes (81%)in control group surpassed the preoperative best-corrected visual acuity of each group.The experimental group was obviously better than control group(P<0.01).The postoperative naked vision of 49 eyes (67%) in experimental group and 27 eyes (39%)in control group were higher at least one line than the preoperative best-corrected visual acuity.The experimental group was obviously better than control group(P<0.01).The remainder astigmatism postoperatively of 47 eyes (64%) in experimental group and 23 eyes (33%)in control group were within ±0.5D.The experimental group was obviously better than control group(P<0.01).The root mean square of higher order aberration value were 0.512±0.117μm in experimental group and 0.635±0.213μm in control group.The root mean square of higher order aberration value in experimental group was smaller than that in control group 3 months postoperatively (P<0.05).Total higher order aberration value of experimental group increased by 30.9% and control group increased by 65.7%.The increase of total higher order aberration in experimental group was smaller than that in control group (P<0.01).There were 71 eyes (97%)in experimental group and 64 eyes (91%)in control group feeling comfortable with visual quality 3 months postoperatively (P<0.05).CONCLUSION:The visual quality of wave-front aberration guided LASIK is better than that of traditional LASIK.Good therapeutic effects can be achieved in iris location combined wave-front aberration guided LASIK in the treatment of higher astigmatism.