AIM:To investigate the relative factors contributing to anxiety in the patients with primary open angle glaucoma (POAG).METHODS:The degrees of depression and anxiety in 82 patients with POAG and 82 non-POAG individuals were assessed using Hamilton pression scale(HAMD),then the incidence of anxiety in two group and the factors contributing to anxiety in POAG group were analyzed.The all collected data were then subjected to χ2 test.RESULTS:The incidence of anxiety in the patients with POAG was 13 cases (16%),significantly higher than that of the non-POAG individuals (5 cases,6%),(P=0.046),and the risk factors contributing to anxiety were sex,age,education,course,visual field.CONCLUSION:The incidence of anxiety in patients with POAG is high,especialy in those female patients with long-course,old,worse education and worse visual function,so,they should be given psychology intervention at the time of the disease’s treatment.