AIM:To investigate the efficacy of intravitreal triamcino-lone acetonide (IVTA) combined with retinal laser photo-coagulation for the treatment of cystoid macular edema (CME) associated with nonischemic central retinal vein occlusion (CRVO).METHODS:Fifty-six eyes of CME associated with noni-schemic CRVO were divided into two groups randomly.IVTA combined with retinal laser photocoagulation group(treat-ment group):30 eyes.Laser photocoagulation group(control group):26 eyes.Best-corrected visual acuity (BCVA),intraocular pressure (IOP),fluorescein fundus angiography(FFA) and optic coherent tomography(OCT) before treatment and at 3 month after treatment in these eyes were examined.40mg/mL IVTA with were performed after 2 weeks of grid pattern retinal laser photocoagulation for CME associated with nonischemic CRVO.RESULTS:Three months after treatment,23 eyes (77%) had improved BCVA,7 eyes (23%)remained the same.Fluorescence leakage relieved had been found by FFA.The average retinal thickness of macular area was (170±32)μm in treatment group.15 eyes(58%) had improved BCVA,11 eyes (42%) remained the same.Relief of fluorescence leakage was found by FFA.The average retinal thickness of macular area was(223±57)μm,in control group.There was statistical significant diffe-rence between treatment group and control group (χ2=4.20,χ2=5.13,P<0.01).CONCLUSION:IVTA combinated with retinal laser photocoagulation for the treatment of CME associated with nonischemic CRVO has better efficacy than retinal laser photocoagulation.