AIM:To investigate the effect of vitrectomy for severe ocular injury with no light perception.METHODS:We retrospectively analyzed 10 patients 10 eyes with severe ocular injury.All affected eyes were performed by one surgeon with standard 3-port pars plana vitrectomy.The mean postoperative follow-up time was 12 months (6-24 months).During the follow-up,we surveyed their visual acuity,the corrected vision,intrao-cular pressure and fundus examination.Some patients were performed with B-ultrasound,UBM,ERG,OCT and fundus photograph.RESULTS:Five eyes had visual acuity of light percep-tion or above.5 eyes had visual acuity of no light percep-tion after operation.In these 5 eyes,2 eyes,because of atrophia bulbi,were performed second surgery with eyeball removal and hydroxyapatite implantation.CONCLUSION:The severe injured eyes with no light perception should not be removed blindly.Vitrectomy may save the visual function of some patients.