AIM:To explore the clinical application of fourier-domain optical coherence tomography (FD OCT) in central serous choroiretinopathy(CSC).METHODS:Fourty patients 40 eyes diagnosed with CSC by fluorescein fundus angiography (FFA) underwent FD OCT to observe the changes of macula,then they were treated with 532 laser,and FD OCT was traced.RESULTS:Neurosensory retina or combined with retinal pigment epithelium(RPE) detachment and RPE fracture were observed.The recovery of visual acuity post-laser therapy was consistent with the loss of macular volume.CONCLUSION:FD OCT could replenish and improve FFA in CSC diagnosis and display a clinical significance for estimated prognosis in CSC post-laser therapy.