·AIM:To approach the effect of the MDA,SOD in the occurrence and development of retinal ultraviolet light damage.·METHODS:Totally 30 Kunming mice were randomly divided into the normal control group and experimental group.The experimental group were divided into the ultraviolet ray illumination 1,2,3,4 weeks groups respec-tively.All mice were raised in cyclic light envioronment for 7 days and then kept in darkness for 36 hours before experiment.The experimental group were exposed to 2200±138Lux illuminations of ultraviolet rays for continu-ously 8 hours every day to establish the model of retinal ultraviolet light damage.The eyes were enucleated after exposured 1,2,3,4 weeks separately the left eyes were examined the SOD activity and the MDA content change of the retinal refining.·RESULTS:There was significant difference of the SOD activity and the MDA content between the control group and the experimental group(P<0.05).·CONCLUSION:Lipin peroxidation and free radical pro-duction have a relationship with the retinal ultra-violet light damage.·