·AIM:To compare the effect of continuous subcutaneous insulin injection(CSII)by using insulin pump and multiple subcutaneous insulin injection(MSII)in treatment of eye diseases in type 2 diabetes mellitus(T2DM)patients during the perioperation period.·METHODS:The study included 320 T2DM patients with eye diseases,who were divided into two groups randomly:CSII group and MSII group.The changes of some clinical indexes were compared between the two groups before and after treatment,including the plasma glucose levels,the duration to achieve the target for plasma glucose,insulin dosage,the incidence of hypoglycemia and complication,the length and expense of hospitalization.·RESULTS:The plasma glucose levels in both groups decreased evidently after the therapy(P<0.01).The plasma glucose 2 hours after meal in CSII group was lower than that in MSII group(P<0.01)with less insulin dosage(P<0.01).The duration to achieve the target for plasma glucose and the length of hospitalization in CSII group was shorter than those in MSII group(P<0.01).The incidence of hypoglycemia and complication was lower than those in MSII group(P<0.01).However,the expense of hospitalization in CSII group was higher than that in MSII group(P<0.01).·CONCLUSION:The insulin pump was safe and effective for T2DM patients with eye diseases during the peri-operation period.·