The hormone has good functions about anti-inflamma-tion,anti-allergy and immunosuppression,improvement of metabolism. Recently reports indicated that any admini-stration route may cause eye pressure increase,especially by the way of eye dropping. Some patients presented the hormone glaucoma such as glaucoma optic nerve harm,the field of vision damage and the vision decrease. In this review,we research and summary the status about intraocular pressure elevation related with local hormone.