AIM:To explore the effects of sodium hyalurantae in complex trabeculectomy. ·METHODS:Case-control studies. 56 eyes with primary glaucoma who need complex trabeculectomy were randomly divided into observation group and control group with 28 eyes in each group. Patients in the observation group were applied the sodium hyalurantae,and the control group were not applied during the operation. The changes in anterior chamber,bleb,IOP and corneal endothelial cells in two groups were observed. ·RESULTS:The anterior chambers of 28 eyes in observation group formed early postoperatively. The shapes of filter blebs in observation group were better than control group at three months after operation. Functional filtering bleb appeared in 27 eyes(96%) in observation group and functional filtering bleb appeared in 26 eyes (93%) in control group. IOP of observation group is slightly higher than that of control group early postoperatively,and three months after operation,IOP of observation group was somewhat lower than that of control group. There was no statistical difference between the corneal endothelial cells of preoperation and postoperation in two groups. ·CONCLUSION:It can make the anterior chamber form better by using sodium hyalurantae in complex trabeculectomy,and it can support filtration path to inhibit scar formation and increase the successful rate of complex trabeculectomy.