AIM:To explore the effect and mechanism of VEGF and Ang-1 on differentiation and maturation of choroidal neovascluarization. METHODS:Mice of CNV model were received intravitreous injection with VEGF or Ang-1,the FFA images and pathological section were analyzed to detect the effects of factor Ang-1 or VEGF. RESULTS:In CNV model mice Ang-1 group was found less later period leakage than the control group,while in VEGF group is more than the control group.The scar was found in pathological tissue section of Ang-1 group,and granulation tissue was found in VEGF and control group. CONCLUSION:Ang-1 can suppress the formation and maturation of CNV and improve the scar formation.