AIM:To observe the clinical effect of the intravitreal bevacizumab(IVB) combined with vitrectomy,retinal photocoagulation and trabeculectomy as a mult-treatment for the neovascular glaucoma(NVG). METHODS:Totally 27 patients 27 eyes which had the NVG secondary from central retinal vein occlusion(CRVO) were enrolled.All eyes accepted the vitrectomy,retinal photocoagulation combined with trabeculectomy 7 days after IVB(0.05mL/1.25mg).The visual acuity,the condition of the new vessels on the iris and the angle of anterior chamber and the intraocular pressure(IOP) were observed 12 months postoperatively. RESULTS:The new vessels on the iris and the angle of anterior chamber regressed completely in 25 eyes(93%), 7 days after IVB and thinned obviously in 2 eyes but not regressed(7%).The mean IOP before the IVB(55.81±4. 65mmHg) and the after(42.07±7.49mmHg) had significant difference(t = 14.973,P<0.01),but still higher than normal level(28-50mmHg).The mean IOP 1 month,3,6, 9 and 12 months after the vitrectomy,retinal photocoagulation and trabeculectomy(14.85±4.56,16.70±3.73,20. 04±6.58,19.30±4.74,19.67±4.12,respectively) mmHg and 7 days after IVB had significant difference(P<0.01). The IOP were controlled completely in 22 eyes(82%), partly controlled in 3 eyes(11%),and not controlled in 2 eyes(7%).The visual acuity of all the eyes was stable and rise slightly. CONCIUSION:IVB as an adjunct method combined with vitrectomy,retinal photocoagulation and trabeculectomy can make the new vessels on the iris and the angle of anterior chamber regression and to lower the IOP,thus it can increase the achievement ratio of the operation and decrease the complication.And the long-term effect is better to cure the protopathy at the same time.