AIM:To study the necessity of laser photocoagulation before laser in situ keratomileusis(LASIK) on the retinal degeneration. METHODS:Totally 49 eyes(49/1631) showed serious peripheral fundus degeneration after routine preoperative examination of 831 cases.Retinal tears were found in 17 eyes,lattice retinal degeneration in 15 eyes and cystoid retinal degeneration in 26 eyes.All of them have been treated with laser photocoagulation by 532nm solid laser. RESULTS:One month after laser photocoagulation, LASIK surgery was performed in laser region which has good pigmentation.There were no complications of retinal detachment during the follow-up period of 3-36 months. CONCLUSION:Detailed examination of fundus before LASIK is necessary.The preventative laser photocoagulation in serious peripheral fundus degeneration is safe and effective.