AIM:To analyse the problems in the early diagnosis and treatment of clinical cases with Vogt-Koyanagi-Harada (VKH) syndrome. METHODS:Twenty-five cases 50 eyes with VKH syndrome were collected and analysed,routine examination of FFA and OCT were performed,its reason and differential diagnosis method were analyzed,most of them were diagnosed correctly,some of them were diagnosed as central serous chorioretinopathy(4 cases),glaucoma(2 cases),optic neurve-retinitis(5 cases).All the cases were given high dose corticosteroise treatment,and examined with OCT after two weeks. RESULTS:After one week,all the patients’ visions recovered to better than 0.5 in 78%of eyes. CONCLUSION:FFA and OCT are the useful methods on early differential diagnosis of the VKH syndrome.Early correct diagnosis for VKH syndrome and high dose corticosteroise treatment are the important factors for the better prognosis.