AIM:To discuss the misdiagnosis course and outcome of acute angle-closure glaucoma. METHODS:Clinical data in diagnosis and treatment of 15 cases of misdiagnosed acute angle-closure glaucoma were to retrospectively analyzed. RESULTS:Totally 3 cases of misdiagnosis were because of self-medication treatment;12 cases of the first medical consultation are leaded to misdiagnosis.2 cases were misdiagnosed as conjunctivitis,6 cases as gastrointestinal diseases,cardiovascular and cerebrovascular disease in 7 cases.Surgical treatments were in 14 cases and conservative treatment in one case.Visual acuity of more than 0.3 were in 5 cases,0.1-0.3 in 3 patients,less than 0.05 in 5 cases and less than 0.1 in 7 cases. CONCLUSION:Patients’s understanding error is their subjective reason of delay in diagnosis and treatment, and physicians should enhance the learning of basic knowledge of glaucoma in order to avoid misdiagnosis.