AIM:To investigate the surgery effect of lacrimal passages dredging,silicon tube implantation and mitomycin C (MMC) retrograde treatment by endoscopy for lacrimal duct obs-truction. METHODS:Totally 106 cases underwent the lacrimal passages dredging,Y-shaped silicon tube implantation, and mitomycin C application after 3 months,and the surgery effect were observed. RESULTS:Lacrimal passages dredging,silicon tube implantation and mitomycin C retrograde treatment by endoscopy extubation,the operation had easy procedure, and very little trauma.A normal life,work,study were recorded.Following-up 3 years:the effective rate of 96.2%or more were in 102 eyes,marked effect accounted for 92.5%(98 eyes),cure rate was in 90 eyes(84.9%) and invalid in 4 eyes(3.8%). CONCLUSION:The above technique is the preferred and supplementary treatment method for lacrimal duct obstruction,which also have less damage,higher success rate,fewer complications and lower operation costs.