AIM:To investigate the clinical effect of the artificial nasolacrimal duct implantation. METHODS:Totally 225 patients 261 eyes with nasolacrimal duct obstruction were implanted artificial nasolacrimal duct by retrograde expand nasolacrimal canal.All patient had nasolacrimal duct angiography examination before and after surgery to compare. RESULTS:Totally 225 patients 261 eyes were implanted artificial nasolacrimal duct,216 patients 252 eyes were operated successfully,the success rate was 96.7%.After the surgery patients were followed up for three months to two years(January 2008-April 2010).The effective rate was 95%after 3 months,91%after 1 year,75%after 2 years. CONCLUSION:Artificial nasolacrimal duct implantation is a simple and high efficiency operation without scar and trauma.