·AIM:To observe the effect of laser-Doppler retinal blood flowmeter and oscillatory potentials(OPs)OS2 of the electroretinogram in diabetic retinopathy(DR).·METHODS:The average blood flow volume(VOL),the blood flow velocity(FLW)and the erythrocyte flow velocity of the vesse(VEL)in the temporal and nasal juxtapapillary retina and the avascular area of temporal and nasal retina were measured with the non-invasive Heidelberg retinal flowmeter(HRF),and OPs OS2 were measured with the ROLAND RETIport electroretinogram in 104 patients 208 eyes with diabetes and 21 patients 42 eyes in normal control group.The patients with diabetes were divided into non-diabetic retinopathy(NDR)group(22 patients,44 eyes)and non-proliferative diabetic retinopathy(NPDR)group(82 patients,164 eyes).NPDR group were svbdivided into 3 groups:phase I,II,III group.The data in each group were statistically analyzed.·RESULTS:The parameter of retinal blood flow of temporal and nasal juxtapapillary retina and the avascular area of temporal and nasal retina in NDR and NPDR group was significantly lower than that in the normal control group(P<0.05).The VOL and FLW of temporal and nasal juxtapapillary retina and the avascular area of temporal and nasal retina in NPDR phase II group was obviously higher than that in the other groups(P<0.05).The VEL of temporal and nasal juxtapapillary retina and the avascular area of temporal and nasal retina in NPDR phase II group were significantly higher than that in NPDR phase I and NDR group(P<0.05).The FLW and the VEL of nasal and temporal juxtapapillary retina and the avascular area of temporal and nasal retina in NPDR phase III group were obviously higher than that in NDR group(P<0.05).Hemoglobin Alc value was positively correlated with degree of diabetic retinopathy(r=0.433,P=0.000).The OPs OS2 in NDR and NPDR group was significantly lower than that in the normal control group(P<0.05),the OPs OS2 of the NPDR phase III and phase II group were significantly lower than that in NPDR phase I and NDR group(P<0.05).·CONCLUSION:As a non-invasive method for mea-surement of retinal blood flow,HRF and OPs OS2 has important value in revealing the mechanism and degree of pathological changes and choice of treatment for DR.·