AIM:To explore the short-term surgery results for secondary epimacular membrane in silicone oil tamponade eyes,and to evaluate the effect influence after internal limiting peeling surgery.·METHODS:It was a case control study. 65 patients 65 eyes with secondary epimacular membrane in silicone oil tamponade who underwent silicone oil removal and epimacular membrane peeling(EMP) combined with or without internal limiting membrane peeling(ILMP) were retrospectively analyzed.They were divided into single EMP group 34 eyes and combined with ILMP group(CILMP) (31 eyes).The follow-up time was more than 3 months. Best corrected visual acuity(BCVA),optical coherence tomography (OCT) and multifocal electroretinogram(mfERG) were exeamined preoperatively and 3 months postoperatively respectively. The change of BCVA,foveal thickness(FT),amplitude density of wave P1 of ring 1 by mfERG were analyzed before and after surgery and the results were also analyzed statistically in both groups.·RESULTS:BCVA,FT and amplitude density of P1 were 4.1±0.3,424±54μm,and 23±7.3nV/deg2 respectively before surgery and they were 4.5±0.5,355±43μm,and 26±8.5nV/deg2 respectively after surgery in EMP group. BCVA,FT and amplitude density of P1 were 4.2±0.1,436±68μm and 24±7.8nV/deg2 before surgery and 4.5±0.4,348±53μm and 27±9.7nV/deg2 after sugery in CILMP group.There was significant difference between preoperation and postoperation in every group regarding BCVA,FT,amplitude of wave P1 of ring 1 by mfERG(P<0.05). But there was no significant difference between the two groups before or after suegery.·CONCLUSION:EMP is an efficient surgery for the treatment of secondary epimacular membrane in silicone oil tamponaded eyes. Combined with ILMP may not benefit econdary epimacular membrane in silicone oil tamponade eyes in short-term after surgery.