AIM:To observe effects of Jolethin combined with argon laser for central serous chorioretinopathy(CSC). ·METHODS:Totally 60 patients 67 eyes with CSC (leakage zone:extrafoveal≥ 250μm) were devided into two groups randomly,and the treatment group included 30 patients 34 eyes who were treated by Jolethin through oral way and photocoagulation with argon laser,while the control group included 30 patients 33 eyes who were only treated by photocoagulation with argon laser. The difference of optic fundi,visual acuity,frequency of laser treatment,healing time,therapeutic effect and the recurrence rate were observed and compared after treatment. ·RESULTS:After treatment,the absorption of leakage by fundus fluorescein angiography was faster in the treatment group than that in the control group,and the difference was statistically significant (P<0.05); The visual acuity in both groups were significantly improved (P<0.01);However,the visual acuity in the treatment group was significantly higher than that of control group (P<0.01). The number of laser treatment was in the treatment group less than that in the control group,the difference was statistically significant (P<0.05); The treatment group were cured in a short time group,the difference was statistically significant (P<0.05); The therapeutic effect of the two groups had a significant difference (P<0.05);the recurrence rate in the treatment group was significantly lower than that in control group (P<0.05). ·CONCLUSION:It is effective to treat CSC (leakage zone:extrafoveal≥ 250μm) by Jolethin combined with argon laser.