AIM:To analyze the change trends of the factor related to the patients with suppurative endophthalmitis in our hospital in recent 10 years and to provide useful information and basis to the prevention and treatment of suppurative endophthalmitis in future. ·METHODS:Totally 357 cases 357 eyes were retrospectively analyed from January 1999 to January 2009 in our hospital. We comparatively analyed the related factor of age,occupation and cause of disease of 357 cases 357 eyes with suppurative endophthalmitis in forward 5 years (January 1999-January 2004)and backward 5 years (February 2004-January 2009)of the recent 10 years. ·RESULTS:Children and middle-aged people constituted the main disease population in recent 10 years,the proportion was 43.7%,34.1% and 35.1%,42.8%,but the proportion of children(43.7%,35.1%)and young people (19.8%,10.8%) were declined markedly(P<0.05),while the proportion of old people(2.4%,11.3%) was increased markedly(P<0.05). Occupational structure that mainly comprehended farmers and students were not changed. The proportion was 41.3%,39.7% and 44.6%,35.5%;the cause of disease had no significant changes,the proportion of the ocular trauma that was the main cause of disease was 88.9% and 87.5%,and in the ocular trauma the proportion of syringe injuries (16.7%,9.1%) was significantly decreased (P<0.05),while the proportion of wire and scissors injuries(21.4%,31.6%) was significantly increased (P<0.05).·CONCLUSION:The children and middle-aged constitute the main disease population in recent 10 years,the proportion of children and young people is on a downward trend,while that of old people is on an upward trend; occupational structure that mainly comprehended farmers and students are not changed; the ocular trauma is the main cause of disease,in which the proportion of syringe injuries is on a downward trend,while the proportion of wire,scissors injuries on an upward trend.