AIM:To discuss the function of early time fresh amniotic membrane transplantation for severe ocular alkali burns.METHODS:The healthy fresh amnion was taken,1-2 days after injury necrosis of the conjunctiva of 20 cases with severe ocular alkali burns were cleared away,the amniotic epidermis face was put on the eyeball surface,interrupted suture,and eyedrops in eyes after bandaged for 2 days were performed.RESULTS:Except a case without timely treatment after burns,eyeball was removed because of corneal melting after operation,the rest eyeballs were successfully kept,no serious symblepharon,vision restored to 0.02 in three eyes,0.05 in two eyes,0.08 in six eyes,0.1 in five eyes,0.12 in two eyes,0.15 in two eyes and 0.3 in one eye.CONCLUSION:Early amniotic membrane transplantation for severe ocular alkali burns is a simple and feasible,practical and effective method.