AIM:To investigate the clinical results of transpupillary thermotherapy(TTT) for patients with retinal pigment epithelium(RPE) lesion in central macular region.METHODS:Thirty-eight cases 39 eyes diagnosed with RPE lesion in central macular region by FFA were treated with a diode laser at 810nm.The treatment range was decided by the range of the RPE leakage,RPE detachment or RPE decompensation.Laser parameters were as follows:the diameters of beam spot varied from 800μm to 3000μm,the power from 100mW to 460mW,the duration 60 seconds,beam spots from 1 to 3.The visual acuity,fundus,central visual field and FFA were followed up.RESULTS:The visual acuity and central visual field were improved after laser treatment.The average visual acuity of 39 eyes was 0.5 and 1 month after treatment were 0.67±0.26 and 0.90±0.31 respectively.The difference was significant(t=5.22,8.41,P<0.01) compared with that before the treatment.2 months after treatment the visual acuities increased in 36 eyes(92%).The average visual acuity and mean sensitivity of the 39 eyes were 0.95±0.34 and 25.46±1.74dB respectively.The difference was significant(t=8.67,8.84,P<0.01) compared with the average visual acuity and mean sensitivity before the treatment.FFA showed that fluorescein leakage stopped in 37 eyes.But 1 case recurred during the follow-up time.CONCLUSION:TTT is effective and safe for RPE lesion in the central macular region.