Diabetic retinopathy is one of the most frequent and the most severe micrangium complications of diabetes mellitus,the fundamental pathology characteristic of DR is breakdown of the blood-retinal barrier and neovascularization.In the later stage of DR,the formation of the epiretinal membrane,which may tractates the retina and produce detachment of the retina,results in progressive deterioration of vision.The pathogenesis is very complex and has not been elucidated completely.Retinal neovascularization results from both increasing of vascular stimulating factor and reducing of vascular inhibiting factor.VEGF,as an important factor promoting angiogenesis,was widely concerned on the pathogenesis of research and treatment of DR recent years.This article aims to explain the effect of VEGF in the pathogenesis of DR.