AIM:To evaluate curative effect of laser combined with compound anisodine for central serous chorioretinopathy(CSC).METHODS:All of 156 cases 158 eyes diagnosed with CSC were divided into two groups.Laser combined with compound anisodine was performed in 86 cases 86 eyes as treatment group;the control group,70 cases 72 eyes,were treated by krypton laser combined with danshen and inosine.The curative effect and recurrent rate were compared in two groups.RESULTS:The cure rate was 94.2% in treatment group,75.0% in control group;in treatment group the average cure time was 34.8±8.6 days,5 cases 5 eyes recurred,however in control group the average cure time was 68.4±16.8 days,18 cases 18 eyes recurred.There was statistically significant difference in the average cure time(P<0.01) and recurrent rate(P<0.05) between two groups.There was significant difference in cure rate in two groups(P<0.01).CONCLUSION:Krypton laser combined with compound anisodine for CSC is effective and safe.The effect which can shorten the course of disease,prevent the progress of photic injure in the macular area and repair the retinal non-treament area,improve the function of retina and reduce the recurrent rate is obvious.