·AIM:To compare the change of intraocular pressure(IOP)and correlative factors in exfoliation syndrome combined with cataract and senile cataract 2 years after phacoemulsification.METHODS:A total of 49 patients 54 eyes with exfoliation syndrome combined with cataract underwent phacoemulsification and intraocular lens(IOL)implantation.Based on IOP,they were divided into exfoliation syndrome combined with cataract(XFS)sub-group(29 cases 31 eyes)and exfoliation syndrome combined with cataract and glaucoma(XFG)sub-group(20 cases 23 eyes).134 senile cataract patients 152 eyes received phacoemulsification and IOL implantation and were selected as a control at the same period;according to IOP,they were divided into cataract group(86 cases 93 eyes)and cataract combined with open angle glaucoma sub-group(48 cases 59 eyes).The exfoliation syndrome combined with cataract group and control group underwent surgery after IOP was normal by medication and the change of IOP was compared within 2 years after phacoemulsification.RESULTS:Preoperative IOP of exfoliation syndrome sub-group was higher than that of the control group(21.85±2.23mmHg vs 18.62±3.12mmHg,P=0.002).Two years after phacoemulsification,IOP lowered in both groups(17.60±3.23mmHg vs 15.08±3.18mmHg,P=0.0037).Statistical analysis showed that it was related with surgical perfusion.IOP of XFG group had significantly decreased.CONCLUSION:The exfoliation syndrome combined with cataract group have significantly lower IOP than the control group 2 years after phacoemulsification.