·AIM:To study the correlation of immune rejection and immune privilege in homogeneity variant mice corneal transplantation model.·METHODS:The experimental animal model of mice normal position corneal graft and allograft was established successfully.Then,we observed the immune rejection of the two kinds graft model.The transplantation corneal survival rate was compared and analyzed according to the Sonoda method.·RESULTS:All the graft corneas following normal position transplantation were alive,compared with only 25% of allograft cornea alive.·CONCLUSION:Immune rejected reaction in mice corneal transplantation is not always happened and immune privilege plays a very important role in cornea graft.·