·AIM:To investigate the effect of vitreous aspiration on the treatment of acute angle-closure glaucoma hard-controlled by drug.·METHODS:Totally 60 cases(60 eyes,male 28,female 32)with acute angle-closure glaucoma enrolled in our hospital,24 hours after drug treatment,intraocular pressure(IOP)were still higher than 21mmHg.IOP was 21-35mmHg in 26 eyes(43%),<35-50mmHg in 18 eyes(30%),more than 50mmHg in 16 eyes(27%).Range of vision was light perception to 0.3.All eyes were treated by pars plana vitreous aspiration treatment(aspiration of vitreous fluid 0.4-1.0mL).·RESULTS:IOP was measured at 3 days after surgery,IOP was≤21mmHg in 14 eyes(23%),<21-35mmHg in 29 eyes(48%),<35-50mmHg in 13 eyes(22%),more than 50 mmHg in 4 eyes(7%);increase of visual acuity was two lines in 28 eyes(47%),increase of visual acuity was1 line in 24 eyes(40%),no increase in visual acuity was 8 eyes(13%);anterior chamber depth deepened in 58 eyes(97%);postoperative hyphema in 16 eyes(27%).After IOP were stable,patients were treated with simple anti-glaucoma surgery in 14 eyes,glaucoma,cataract and intraocular lens(IOL)exchange surgery in 28 eyes,cataract extraction and IOL implantation in 18 eyes.During the postoperative follow-up of 6-12 months,IOP was≤17mmHg in 54 eyes,IOP≤21mmHg in 4 eyes,IOP was <21-35mmHg in 2 eyes.Retinal detachment,cystoid macular edema,etc,were not found.·CONCLUSION:The vitreous aspiration in acute angle-closure glaucoma which is difficult to control by drug has a significant effect of lowering IOP.This method provide safe and reliable conditions for the implementation of a variety of glaucoma surgery and help protect and restore visual function.·