AIM:To investigate the inhibition of LMWH (low-molecule-weight heparin) added in irrigating solution to fibrin exudation in anterior chamber after the surgery of ECCE (extra-capsular cataract extraction) for infant New Zealand rabbits, and the influence on the blood-aqueous barrier. METHODS:Twenty infant rabbits were randomly divided into trial group and control group. ECCE was performed on the right eyes of all rabbits in the two groups, and Linger solution was used as irrigating solution during the surgery. Differently, LMWH——Clexane was added into the irrigating solution in trial group, and the concentration was 6IU/mL, while in control group, only Linger solution was used. Fibrin exudation in anterior chamber, corneal edema and hemorrhage in anterior chamber were observed at the 1st, 3rd, 7th and 14th day after surgery, and the fluorescence concentration in aqueous humor at above time spots was tested. RESULTS:At the 1stand 3rd day after surgery, fibrin exudation in trial group was obviously weaker than in control group, and the difference was significant (P=0.001, 0.010). At the 7th day after surgery, there was no significant difference between the two groups, and no fibrin exudation was observed at the 14th day after surgery in both groups. Corneal edema was observed in both groups at the 1st and 3rd day, and the difference was not significant (P=0.702 and 0.362). Corneal edema disappeared on the 7th day in both groups. No hemorrhage was found in two groups at any time. The fluorescence concentration in aqueous humor at any time spot in both trial and control groups was not significantly different (P=0.569, 0.152, 0.696 and 0.703). CONCLUSION:Six IU/mL LMWH added into the intraocular irrigating solution can safely and effectively inhibit intraocular fibrin exudation and inflammation, and no side-effect was found. But it hasn’t direct protection to blood-aqueous barrier of infant rabbit.