AIM:To observe the effect of orthokeratology on controlling or slowing the development of myopia in teenagers at different age group. METHODS:A total of 212 cases(315 eyes) aged from 7 to 18 years old with -1.00--5.00DS and astigmatism ≤-1.50DC were observed. Orthokeratology was used for teenager myopia patients after correction. All cases were averagely divided into four groups according to age. The patients with uncorrected visual acuity(UCVA) ≥1.0 and ≥0.8 were analyzed at 6, 12, 24 months. RESULTS:Patients after wearing orthokeratology for 6 months, UCVA was ≥1.0 in all cases. 12 months later, UCVA≥1.0 was 38.2%, ≥0.8 was 61.8% in Ⅰ group; Ⅱ group:UCVA≥1.0 in 54.0%, ≥0.8 in 46.0%; Ⅲ group:UCVA≥1.0 in 62.2%, ≥0.8 in 37.8%; Ⅳ group:UCVA≥1.0 in 100%. 24 months later, Ⅰ group:UCVA≥1.0 in 7.3%, ≥0.8 in 8.9%; Ⅱ group:UCVA≥1.0 in 21.6%, ≥0.8 in 15.8%; Ⅲ group:UCVA≥1.0 in 37.8%, ≥0.8 in 16.2%; Ⅳ group:UCVA≥1.0 in 62.5%, ≥0.8 in 37.5%. CONCLUSION:Orthokeratology have a good therapeutic effect with increasing age on controlling or slowing the development of myopia in teenagers at different age group. It is a selection method with rapid effect, noninvasive and reversible shaping.