AIM:To explore the clinical practicality and efficacy of small incision non-ultrasonic therapy under topical anesthesia associated with peribulbar anesthesia in the operation of preventing blinding.METHODS:Totally 180 cases 180 eyes were selected.They underwent small incision non-ultrasonic therapy under topical anesthesia associated with peribulbar anesthesia.RESULTS:The rate of anesthesia satisfaction was 97.2%.123 eyes(68.3%) got a visual acuity of 0.5 or more one day after operation,and the rate increased to 86.7% one week after operation.No serious complications occurred and the effects were satisfactory.CONCLUSION:It is safe and practical of using topical anesthesia associated with peribulbar anesthesia in the small incision non-ultrasonic therapy of preventing blinding.It also improves the quantity of the operation of blindness prevention.