AIM:To investigate the effect of loteprednol etabonate ophthalmic suspension combined with deproteinized calf blood extract eye gel in treating various kinds of ocular inflammation and corneal nebula caused by trauma.METHODS:A self-control study was performed at our hospital.Patients with corneal nebula caused by various kinds of corneal diseases from February 2009 to October 2010 were selected.The effect of loteprednol etabonate opthalmic suspension combined with deproeinized calf blood extract eye gel during different periods was analyzed.RESULTS:According to the development of the corneal nebula,the patients were divided into four different groups:no more than 1 month group(24 patients,30 eyes),1-2 months group(23 patients,30 eyes),2-3 months group(25 patients,30 eyes) and more than 3 months group(25 patients,30 eyes).The cure rate of the 24 patients(30 eyes) in the no more than 1 month group was 80% and the symptom relief rate was 20%.The rate of symptom relief and the inefficiency of the 1-2 months group were 53.3% and 46.7% separately.And the 2-3 months group were 13.3%(the rate of symptom relief) and 86.7%(the rat of inefficiency).The inefficiency in more than 3 months group was 100%.CONCLUSION:The combination of loteprednol etabonate ophthalmic suspension and deproteinized calf blood extract eye gel is effective in treating various kinds of corneal nebula at the early stage and can enhance the vision as well as improve the progress of the corneal clearing restoration significantly.