AIM:To observe the effect and prognosis in patients with proliferative diabetic retinopathy(PDR) five years after panretinal photocoagulation(PRP).METHODS:Totally 92 cases(149 eyes) with PDR were reviewed one month,three months,six months,one year and then half-yearly after PRP treatment,and reviewed FFA after three months,if necessary,added photocoagulation.All patients were reviewed for the statistics and the conclusion.RESULTS:Visual acuity improved in 52 eyes,unchanged in 71 eyes,decreased in 26 eyes.So far,the final corrected visual acuity after PRP:19 eyes was≤0.01,64 eyes between>0.01-0.1,58 eyes between>0.1-0.5,8 eyes>0.5.During the follow-up after laser blood glucose level was controlled within the normal range in 63 eyes,five years later only six eyes were complicated with vitreous hemorrhage,tractive retinal detachment and other serious complications,accounting for 9.5%,while in 29 eyes of unsatisfied blood glucose levels,9 eyes(31%) occurred with above situation.CONCLUSION:The early detection and timely treatment and regular follow-up observations to reduce diabetic blindness is entirely possible.For the PDR patients,immediately PRP treatment after diagnosed and to develop regular follow-up plan,and as necessary,to review the FFA or additional laser should be conducted.At the same time,that formal medical treatment and satisfied blood glucose control can effectively reduce or delay the development of PDR should be clarified to the patient.