AIM:To observe the clinical effect of lid-wiper epitheliopathy(LWE) treated by artificial tears combined with basic fibroblast growth factor(bFGF).METHODS:Eighty-six cases were divided into two groups randomly.The treated group were treated with preservative-free artificial tears(3g/L Hialid) combined with bFGF and the control group were treated with simple preservative-free artificial tears.After 3 weeks of treatment,all patients were rechecked.The observed indexes included lid-wiper staining(fluorescein and lissamine green dyes) and questionnaire survey of evaluation of dry eye.The difference of these indexes were compared between before and after treatment.RESULTS:The therapeutic effect of LWE in treated group was excellent in 74 eyes(86%),effective in 12(14%) and cure rate was 86%;versus therapeutic effect in control group was excellent in 51 eyes(59%),effective in 34 eyes(40%),ineffective in 1 eye(1%),and cure rate was 59%.There was statistically significant difference between the two groups(P<0.05).CONCLUSION:Artificial tears combined with bFGF play significant therapeutic effect in treating LWE.