AIM:To estimate the therapeutic effects of pterygium excision combined with corneal limbal stem cells transplantation using biomedical fibrin glue in the treatment of pterygium.METHODS:In all the 59 cases(60 eyes),group 1:34 eyes received pterygium resection+limbal stem cell transplantation using biomedical fibrin glue.Group 2:26 eyes received pterygium resection+limbal stem cell transplantation without biomedical fibrin glue.RESULTS:Group 1 needed shorter time in the surgery than the group 2.Meanwhile the patients who received pterygium resection+limbal stem cell transplant using biomedical fibrin glue had less postoperative symptoms of stimulation.Limbal stem cell transplantation adhesion of 5 eyes(19%) was poor and sclera was exposed in group 2.Graft in fibrin glue group healed well,no significant local conjunctival scarring formed;the control group suffered from varying degrees of conjunctival scarring by suture irritation.After 6 months’ follow-up,both groups had no pterygium recurrence.CONCLUSION:The patients who received pterygium resection+limbal stem cell transplantation using biomedical fibrin glue have lower recurrent rate and less post-operative symptoms of stimulation.Using biomedical fibrin glue is an effective method to cope with pterygium.